Description

1-Phenyl-1H-Pyrazole-5-Carbonyl Chloride is a versatile and highly reactive acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 1-phenylpyrazole-5-carbonyl moiety, a key structural motif in the development of active pharmaceutical ingredients and functional materials. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory pathways.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the pyrazole core contributes to biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers with specific electronic or photophysical properties.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D.
• Academic and Industrial R&D: Fundamental building block in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	1-Phenyl-1H-Pyrazole-5-Carbonyl Chloride
CAS No.	423768-37-0
Molecular Formula	C10H7ClN2O
Molecular Weight	206.63 g/mol
Synonyms	1-Phenyl-1H-pyrazole-5-carbonyl chloride; 1-Phenylpyrazole-5-carbonyl chloride; 1-Phenyl-1H-pyrazole-5-carboxylic acid chloride; 5-Carboxy-1-phenylpyrazole chloride; 1-Phenylpyrazole-5-carboxylic acid chloride; 423768-37-0; 1-Phenyl-1H-pyrazol-5-yl carbonyl chloride
EINECS	Contact for details

Quality Control

Our 1-Phenyl-1H-Pyrazole-5-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.