Description

9-Cis Acitretin is a synthetic retinoid and a key isomer of the active metabolite of etretinate. This compound is of significant interest in pharmaceutical research and development due to its specific biological activity profile. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel dermatological and oncological therapeutics. The product is supplied with a focus on high purity and batch-to-batch consistency to support critical R&D and manufacturing processes.

Application

• As a reference standard in analytical method development and quality control for pharmaceutical products.
• In preclinical research for studying retinoid receptor pathways and mechanisms of action.
• For the development of new dermatological treatments, particularly for severe psoriasis and other keratinization disorders.
• As a key intermediate or active pharmaceutical ingredient (API) in the synthesis of specialized retinoid-based medications.
• In academic and institutional research exploring the role of retinoids in cell differentiation and proliferation.
• For investigational new drug (IND) applications and supporting clinical trial material.

Basic Information

Product Name	9-Cis Acitretin
CAS No.	419534-31-9
Molecular Formula	C21H26O3
Molecular Weight	326.43 g/mol
Synonyms	9-cis-Acitretin; (2E,4E,6Z,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic Acid; Neotigason (cis-isomer); 9Z-Acitretin; all-trans-Acitretin isomer; Ro 13-7652/000 (cis form)
EINECS	Contact for details

Quality Control

Our 9-Cis Acitretin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, related substances, and residual solvents. We support compliance with cGMP standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) at a controlled room temperature of 15-25°C (59-77°F) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.