Description

Lenvatinib is a potent, orally administered multi-kinase inhibitor targeting key signaling pathways involved in tumor angiogenesis and proliferation. This high-purity active pharmaceutical ingredient (API) is critical for the development and manufacturing of targeted cancer therapeutics. It is primarily utilized by pharmaceutical companies and research institutions engaged in oncology drug development and clinical trials.

Application

• Pharmaceutical API: Primary active ingredient in the formulation of anti-cancer medications.
• Oncology Research: A key reference standard and investigational compound in preclinical studies for various solid tumors.
• Drug Development: Used in the synthesis and process development of novel tyrosine kinase inhibitor (TKI) therapies.
• Clinical Trial Material (CTM): Sourced for the production of batches used in human clinical studies.
• Generic Drug Manufacturing: Essential for companies developing bioequivalent versions of approved lenvatinib-based drugs.
• Biochemical Research: Tool compound for studying VEGFR, FGFR, PDGFR, RET, and KIT signaling pathways in cellular models.

Basic Information

Product Name	Lenvatinib
CAS No.	417716-92-8
Molecular Formula	C21H19ClN4O4
Molecular Weight	426.86 g/mol
Synonyms	E7080; Lenvima (trade name); 4-[3-Chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinolinecarboxamide; N-[4-[[3-Chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]phenyl]methyl]-7-methoxy-4-quinolinamine; Lenvatinib Mesylate (salt form); Lenvatinib free base
EINECS	Contact for details

Quality Control

Our Lenvatinib is manufactured under strict quality systems to ensure it meets the stringent requirements for pharmaceutical use. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and LC-MS. A Certificate of Analysis (COA) is provided with each shipment, detailing compliance with in-house specifications aligned with ICH guidelines. We support development with regulatory starting material (RSM) documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) in the original packaging to maintain stability and prevent degradation. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.