Description

Belinostat (PXD101) is a potent and selective histone deacetylase (HDAC) inhibitor. This compound is of significant interest for its role in epigenetic regulation and its potential in targeted cancer therapy research. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies engaged in oncology drug discovery and development.

Application

• Oncology Research: A key investigational agent for studying the mechanisms of histone deacetylase inhibition in various cancer cell lines.
• Drug Discovery & Development: Serves as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical-stage therapeutic programs.
• Biochemical Assays: Used as a potent inhibitor in enzymatic assays to study HDAC activity and screen for novel therapeutic compounds.
• Epigenetics Studies: A critical tool for researchers exploring chromatin remodeling, gene expression, and cellular differentiation processes.
• Reference Standard: Employed in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.

Basic Information

Product Name	Belinostat (PXD101)
CAS No.	414864-00-9
Molecular Formula	C15H14BrN3O5S
Molecular Weight	428.26 g/mol
Synonyms	PXD101; Beleodaq; N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide; (2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]prop-2-enamide; HDAC Inhibitor PXD101; LS-104; NSC 726630
EINECS	Contact for details

Quality Control

Our Belinostat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets high-purity research-grade standards. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be kept under inert conditions or in a desiccator after opening to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.