Description

2-[2-(2,3-Difluorophenyl)Ethyl]-n-[1-(2-Methoxyethyl)-4-Piperidinyl]-4-Oxo-n-[[4'-(Trifluoromethyl)[1,1'-Biphenyl]-4-Yl]Methyl]-1,8-Naphthyridine-1(4H)-Acetamide is a complex, high-purity pharmaceutical intermediate with a defined molecular structure. This compound matters for its role as a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated small-molecule design. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new chemical entities (NCEs).
• API Synthesis: Used in the multi-step synthesis of potential active pharmaceutical ingredients, especially for central nervous system (CNS) or oncology targets.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery.
• Process Development: Utilized for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and validation.
• Custom Synthesis: Acts as a starting material for the custom synthesis of more complex, proprietary molecules for client-specific projects.

Basic Information

Product Name	2-[2-(2,3-Difluorophenyl)Ethyl]-n-[1-(2-Methoxyethyl)-4-Piperidinyl]-4-Oxo-n-[[4'-(Trifluoromethyl)[1,1'-Biphenyl]-4-Yl]Methyl]-1,8-Naphthyridine-1(4H)-Acetamide
CAS No.	412950-27-7
Molecular Formula	C41H38F5N3O3
Molecular Weight	715.76 g/mol
Synonyms	412950-27-7; 1,8-Naphthyridine-1(4H)-acetamide, 2-[2-(2,3-difluorophenyl)ethyl]-N-[1-(2-methoxyethyl)-4-piperidinyl]-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-; BMS-820836 (developmental code); BMS 820836; BMS820836; 2-(2-(2,3-Difluorophenyl)ethyl)-N-(1-(2-methoxyethyl)piperidin-4-yl)-4-oxo-N-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-1,4-dihydro-1,8-naphthyridine-1-acetamide
EINECS	Contact for details

Quality Control

Our 2-[2-(2,3-Difluorophenyl)Ethyl]-n-[1-(2-Methoxyethyl)-4-Piperidinyl]-4-Oxo-n-[[4'-(Trifluoromethyl)[1,1'-Biphenyl]-4-Yl]Methyl]-1,8-Naphthyridine-1(4H)-Acetamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm
Assay	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.