Description

2-Benzoxazolecarbonyl Chloride (9Ci) is a versatile and highly reactive acid chloride derivative of benzoxazole, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the benzoxazolecarbonyl moiety, a key structural feature in various high-performance materials and active compounds. This intermediate is essential for research and development chemists and process engineers working in the pharmaceutical, agrochemical, and specialty chemical industries, where it facilitates the creation of novel molecules with targeted properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing heterocyclic benzoxazole scaffolds for therapeutic applications.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the benzoxazole core contributes to biological activity.
• Polymer & Material Science: Acts as a monomer or modifying agent for creating specialized polymers, coatings, and liquid crystals with enhanced thermal or optical properties.
• Organic Ligand Preparation: Employed in the synthesis of complex organic ligands used in catalysis and metal-organic frameworks (MOFs).
• Peptide & Bioconjugate Chemistry: Useful as a coupling reagent or for introducing fluorescent or affinity tags into biomolecules for research and diagnostic purposes.
• Dye & Pigment Manufacturing: Serves as an intermediate in the production of specialized dyes and optical brighteners.

Basic Information

Product Name	2-Benzoxazolecarbonyl Chloride (9Ci)
CAS No.	408538-63-6
Molecular Formula	C8H4ClNO2
Molecular Weight	181.57 g/mol
Synonyms	2-Benzoxazolecarbonyl chloride; Benzoxazole-2-carbonyl chloride; 1,3-Benzoxazole-2-carbonyl chloride; 2-Carboxybenzoxazole chloride; 2-(Chlorocarbonyl)benzoxazole; 2-Benzoxazolylcarbonyl chloride; 408538-63-6 (CAS); BOCC
EINECS	Contact for details

Quality Control

Every batch of 2-Benzoxazolecarbonyl Chloride is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthetic processes. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC/NMR), identity (IR), and impurity profiles. Our quality system is designed to support cGMP and ISO standards for advanced chemical intermediates, ensuring traceability and compliance for regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.