Description

4-Morpholineacetyl Fluoride, α-Oxo- (9Ci) is a specialized fluorinated building block and a key intermediate in advanced organic synthesis. Its value lies in its unique α-oxo acyl fluoride moiety, which offers high reactivity for selective acylation and fluorination reactions under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for constructing complex heterocycles and peptide mimetics.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, especially protease inhibitors and kinase-targeted therapies.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides with improved efficacy and environmental profiles.
• Peptidomimetic Chemistry: Enables the efficient introduction of morpholine and fluorinated carbonyl groups into peptide backbones to enhance metabolic stability.
• Material Science Research: Serves as a precursor for functionalized polymers and specialty coatings with tailored surface properties.
• Fluorination Reagent: Acts as a source of the fluorocarbonyl group for introducing fluorine atoms into complex molecular architectures.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed and other transition metal-mediated coupling reactions to form carbon-carbon bonds.

Basic Information

Product Name	4-Morpholineacetyl Fluoride, α-Oxo- (9Ci)
CAS No.	408530-75-6
Molecular Formula	C6H8FNO3
Molecular Weight	161.13 g/mol
Synonyms	2-Oxo-2-(morpholin-4-yl)acetyl Fluoride; 4-Morpholineglyoxyloyl Fluoride; Morpholine-4-glyoxyloyl Fluoride; α-Oxo-4-morpholineacetyl Fluoride; 2-(Morpholin-4-yl)-2-oxoacetyl Fluoride; (Morpholin-4-yl)oxoacetyl Fluoride; 4-Morpholinecarbonylformyl Fluoride
EINECS	Contact for details

Quality Control

Every batch of 4-Morpholineacetyl Fluoride, α-Oxo- (9Ci) is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and process chemistry. A detailed Certificate of Analysis (COA) confirming identity, purity (typically ≥95% by HPLC/NMR), and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (¹H, ¹³C, ¹⁹F)
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.