Description

Dovitinib CAS NO 405169-16-6 is a potent and selective small-molecule inhibitor targeting multiple receptor tyrosine kinases (RTKs), including fibroblast growth factor receptors (FGFRs) and vascular endothelial growth factor receptors (VEGFRs). This compound is a critical research tool and pharmaceutical intermediate for developing targeted cancer therapies. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and contract manufacturing organizations (CMOs) focused on oncology drug discovery and development.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the preclinical and clinical development of novel anti-cancer drugs.
• Oncology Drug Discovery: Used as a potent biochemical tool to study signaling pathways involving FGFR, VEGFR, and PDGFR, aiding in target validation and mechanism-of-action studies.
• Kinase Profiling & Selectivity Assays: Employed in high-throughput screening (HTS) and enzymatic assays to evaluate the potency and selectivity profile of new kinase inhibitor candidates.
• Biomedical Research: Facilitates in vitro and in vivo studies investigating tumor angiogenesis, proliferation, and metastasis in various cancer cell lines and animal models.
• Chemical Synthesis: Acts as a sophisticated building block for the synthetic preparation of analogs and derivatives for structure-activity relationship (SAR) studies.
• GMP Manufacturing: Supplied as a high-purity intermediate for the current Good Manufacturing Practice (cGMP) synthesis of the finished drug substance.

Basic Information

Product Name	Dovitinib
CAS No.	405169-16-6
Molecular Formula	C₂₁H₂₁FN₆O
Molecular Weight	392.43 g/mol
Synonyms	TKI-258; CHIR-258; Dovitinib Dilactic Acid; Dovitinib Lactate; (1E)-1-[5-[(5-Fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-3-(4-methylpiperazin-1-yl)urea; 1-[5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-3-(4-methyl-1-piperazinyl)urea
EINECS	Contact for details

Quality Control

Our Dovitinib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and heavy metals. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures material suitable for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.