Description

Panobinostat is a potent and selective histone deacetylase (HDAC) inhibitor, a critical class of compounds for epigenetic research and therapeutic development. Its primary value lies in its ability to modulate gene expression and induce apoptosis in cancer cells, making it a vital tool for oncology research and drug discovery. This compound is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel cancer therapies and studying chromatin biology.

Application

• Oncology Research: A key investigational agent for studying the mechanisms of histone deacetylase inhibition and its effects on tumor cell proliferation and death.
• Drug Discovery & Development: Serves as a reference standard, active pharmaceutical ingredient (API), and lead compound in the development of new HDAC-targeted cancer therapeutics.
• Biochemical Assays: Used in in vitro enzymatic assays to screen for HDAC activity and evaluate the potency of novel inhibitors.
• Preclinical Studies: Employed in cell culture and animal models to investigate pharmacokinetics, pharmacodynamics, and efficacy profiles for hematological and solid tumors.
• Epigenetics Research: A fundamental tool for exploring the role of acetylation in gene regulation, chromatin remodeling, and cellular differentiation.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	Panobinostat
CAS No.	404950-80-7
Molecular Formula	C₂₁H₂₃N₃O₂
Molecular Weight	349.43 g/mol
Synonyms	LBH-589; NVP-LBH589; Farydak; (2E)-N-Hydroxy-3-[4-[[(2S)-2-(1H-indol-3-ylmethyl)-1-methyl-2-pyrrolidinyl]methoxy]phenyl]-2-propenamide; Panobinostat (LBH589); LBH589; HDAC Inhibitor LBH589
EINECS	Contact for details

Quality Control

Our Panobinostat is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements for preclinical and analytical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.