Description

2,4(1H,3H)-Pyrimidinedione, 1-β-L-Ribofuranosyl-, 4-Oxime (9Ci) is a specialized nucleoside derivative with a modified pyrimidine base, serving as a critical building block in advanced pharmaceutical and biochemical research. Its primary value lies in its role as a key intermediate for the synthesis of novel antiviral and anticancer agents, particularly in the development of nucleoside analogs. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and related pathways.
• Antiviral Agent Development: Serves as a core scaffold for creating analogs that target viral polymerases (e.g., for hepatitis or herpes viruses).
• Oncology Research: Investigated for the development of chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Academic & Contract Research: Utilized in universities and CROs for fundamental research in medicinal chemistry and molecular biology.

Basic Information

Product Name	2,4(1H,3H)-Pyrimidinedione, 1-β-L-Ribofuranosyl-, 4-Oxime (9Ci)
CAS No.	402725-23-9
Molecular Formula	C9H13N3O6
Molecular Weight	259.22 g/mol
Synonyms	1-β-L-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione 4-oxime; 4-Oximouridine (L-isomer); L-4-Oximouridine; 1-((2R,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-2,4-dihydroxypyrimidine 4-oxime; β-L-Uridine 4-oxime; Uridine, 4-oxime, L-; 4-(Hydroxyimino)-1-β-L-ribofuranosyl-2(1H)-pyrimidinone
EINECS	Contact for details

Quality Control

Every batch of our 2,4(1H,3H)-Pyrimidinedione, 1-β-L-Ribofuranosyl-, 4-Oxime (9Ci) is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure the material meets the stringent requirements for research and development use. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed HPLC purity, identity confirmation (IR, NMR), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.