Description

D-Erythro-Pentitol, 1,4-Anhydro-3-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2-Deoxy-5-o-[(1,1-Dimethylethyl)Dimethylsilyl]- is a sophisticated, high-purity chemical intermediate featuring protective groups, designed for advanced synthetic applications. This compound matters because it provides a critical, protected building block for the controlled synthesis of complex nucleoside analogs and carbohydrate derivatives, enabling research in novel therapeutic areas. It is primarily needed by pharmaceutical R&D teams, process chemists, and academic researchers focused on developing antiviral agents, anticancer drugs, and other bioactive molecules where precise stereochemistry is paramount.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of nucleoside-based active pharmaceutical ingredients (APIs).
• Antiviral Drug Research: Used in the development of novel antiviral compounds, particularly those targeting viral polymerases.
• Anticancer Agent Development: Serves as a precursor for creating modified nucleosides with potential anticancer activity.
• Carbohydrate Chemistry: Employed in the synthesis of complex, selectively protected sugar derivatives and oligosaccharides.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the commercial-scale production of specialty chemicals.
• Academic & Institutional Research: A valuable tool for studying glycosylation reactions, protecting group strategies, and reaction mechanisms.
• Bioconjugation & Probe Synthesis: Can be used to create labeled nucleotides or carbohydrate probes for diagnostic and biochemical studies.

Basic Information

Product Name	D-Erythro-Pentitol, 1,4-Anhydro-3-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2-Deoxy-5-o-[(1,1-Dimethylethyl)Dimethylsilyl]-
CAS No.	401813-07-8
Molecular Formula	C32H42O6Si
Molecular Weight	550.76 g/mol
Synonyms	1,4-Anhydro-3-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-5-O-[(1,1-dimethylethyl)dimethylsilyl]-D-erythro-pentitol; 5-O-(tert-Butyldimethylsilyl)-3-O-(4,4'-dimethoxytrityl)-1,4-anhydro-2-deoxy-D-erythro-pentitol; 3'-O-DMT-5'-O-TBDMS-1,2-dideoxy-D-ribitol 1,4-anhydride; DMT-protected anhydro ribitol derivative; TBDMS-DMT Anhydroribitol; Protected Anhydroribitol Intermediate; 1,4-Anhydro-2-deoxy-3-O-(4,4'-dimethoxytrityl)-5-O-(tert-butyldimethylsilyl)-D-erythro-pentitol
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced and tested under strict quality management systems to ensure identity, purity, and consistency. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry for comprehensive characterization. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, purity, and the absence of specific impurities. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.