Description

M27.3'-Ogp3G (Arca Cap Analog) is a specialized nucleotide analog designed for the synthesis of capped mRNA. This product is critical for enhancing mRNA stability and translational efficiency, which are paramount for the development of advanced therapeutics and vaccines. It is an essential reagent for biotechnology and pharmaceutical companies engaged in mRNA research, process development, and large-scale GMP manufacturing.

Application

• mRNA Vaccine Production: A key raw material for synthesizing 5'-capped mRNA constructs used in prophylactic and therapeutic vaccines.
• Therapeutic mRNA Development: Enables the production of capped mRNA for protein replacement therapies, cancer immunotherapies, and gene editing applications.
• In Vitro Transcription (IVT): Used as a cap analog in enzymatic mRNA synthesis reactions to ensure high capping efficiency.
• Research & Development: Supports basic and applied research in molecular biology, virology, and translational medicine.
• Process Development & Scale-up: Serves as a critical component in optimizing and scaling mRNA manufacturing processes for clinical and commercial supply.
• CRISPR/Cas9 System Delivery: Facilitates the synthesis of capped guide RNA (gRNA) or Cas9 mRNA for gene editing tools.

Basic Information

Product Name	M27.3'-Ogp3G (Arca Cap Analog)
CAS No.	400806-46-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ARCA (Anti-Reverse Cap Analog); 3'-O-Me-m7G(5')ppp(5')G; 7-methyl-3'-O-methyl-guanosine-5'-triphosphate-5'-guanosine; CleanCap® AG analog; m7G(5')ppp(5')Gm; Cap 1 structure analog; mRNA capping reagent; Modified nucleotide cap analog
EINECS	Contact for details

Quality Control

Every batch of M27.3'-Ogp3G (Arca Cap Analog) is manufactured and tested under a rigorous quality management system. We ensure compliance with high-purity standards suitable for pharmaceutical and biotech applications. Comprehensive analytical testing, including HPLC for purity and identity confirmation, is performed. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.