Description

5'-Guanylic Acid, 3'-o-Methyl- is a chemically modified nucleotide derivative, specifically a methylated analog of guanosine monophosphate. This modification is critical for research into RNA structure, function, and metabolism, offering a valuable tool for probing enzymatic activity and nucleic acid interactions. It is primarily utilized by researchers and developers in the fields of biochemistry, molecular biology, and pharmaceutical R&D for nucleotide analog synthesis and metabolic pathway studies.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for methyltransferases and nucleotidyltransferases.
• Nucleotide Analog Synthesis: Serves as a key intermediate or building block for the synthesis of modified oligonucleotides and nucleoside prodrugs.
• RNA Metabolism Studies: Employed to investigate RNA processing, stability, and degradation pathways where methylation plays a regulatory role.
• Pharmaceutical Development: Explored in early-stage research for potential antiviral or anticancer therapeutic agents targeting nucleic acid synthesis.
• Diagnostic Reagent Formulation: Can be utilized in the development of specialized assay kits for detecting specific enzymatic activities.

Basic Information

Product Name	5'-Guanylic Acid, 3'-o-Methyl-
CAS No.	400806-41-9
Molecular Formula	C11H16N5O8P
Molecular Weight	377.25 g/mol
Synonyms	3'-O-Methylguanosine 5'-monophosphate; 3'-O-Methyl-GMP; Guanosine-5'-monophosphate, 3'-O-methyl-; 3'-Methyl GMP; 5'-GMP 3'-methyl ether; 3'-O-Methylguanylic acid; GMP 3'-methyl ester
EINECS	Contact for details

Quality Control

Our 5'-Guanylic Acid, 3'-o-Methyl- is produced under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (UV, NMR). A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.