Description

3-Isothiazolecarbonyl Chloride (7Ci,9Ci) is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. Its core value lies in its function as a versatile acylating agent, enabling the efficient introduction of the isothiazolecarbonyl moiety into target molecules. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the production of advanced fungicides, herbicides, and insecticides, leveraging the bioactivity of the isothiazole ring.
• Material Science Research: Serves as a precursor for functional polymers and advanced materials with specific electronic or surface properties.
• Chemical Biology & Proteomics: Employed in the design of activity-based probes (ABPs) and affinity tags for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Isothiazolecarbonyl Chloride (7Ci,9Ci)
CAS No.	49672-77-7
Molecular Formula	C4H2ClNOS
Molecular Weight	147.58 g/mol
Synonyms	3-Isothiazolecarbonyl chloride; Isothiazole-3-carbonyl chloride; 1,2-Thiazole-3-carbonyl chloride; 3-Carboxyisothiazole chloride; 3-Isothiazolylcarbonyl chloride; 3-Isothiazole carboxylic acid chloride; 3-Isothiazolecarbonylchloride; 3-Isothiazole acid chloride
EINECS	Contact for details

Quality Control

Our 3-Isothiazolecarbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.