Description

2-Butenoyl Chloride, 2-Methyl- is a highly reactive acid chloride derivative of 2-methyl-2-butenoic acid. This compound serves as a crucial acylating agent and versatile building block in advanced organic synthesis, enabling the efficient introduction of the 2-methyl-2-butenoyl moiety. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs), crop protection agents, and functional monomers.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), particularly in medicinal chemistry.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators.
• Polymer Chemistry: Acts as a monomer or co-monomer for creating specialty polymers with tailored properties, such as acrylic resins.
• Fine Chemical Production: Essential reagent for manufacturing dyes, pigments, and other performance chemicals.
• Bioconjugation & Peptide Chemistry: Employed in modifying biomolecules, peptides, and proteins for research and diagnostic applications.
• Material Science Research: Used in surface modification and the development of new functional materials.

Basic Information

Product Name	2-Butenoyl Chloride, 2-Methyl-
CAS No.	49651-33-4
Molecular Formula	C5H7ClO
Molecular Weight	118.56 g/mol
Synonyms	2-Methyl-2-butenoyl chloride; 2-Methylcrotonoyl chloride; Tiglyl chloride; (E)-2-Methyl-2-butenoyl chloride; 2-Butenoyl chloride, 2-methyl-; 2-Methylbut-2-enoyl chloride; 3-Methylcrotonoyl chloride
EINECS	256-400-5

Quality Control

Our 2-Methyl-2-butenoyl chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including assay by GC or titration and impurity profiling, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) or as specified for specific grades. Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Acid Value	Contact for details
Density (at 20°C)	~1.08 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.