Description

m-tert-Butylphenyl Chloroformate is a versatile and highly reactive chloroformate ester, widely used as a key reagent in organic synthesis and pharmaceutical manufacturing. Its primary value lies in its role as a protecting group and coupling agent, particularly for the introduction of the Boc (tert-butoxycarbonyl) group in peptide synthesis and for the preparation of active pharmaceutical intermediates. This compound is essential for research laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking reliable, high-purity building blocks.

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent for introducing the tert-butoxycarbonyl (Boc) protecting group in the multi-step synthesis of peptides and complex organic molecules.
• Peptide Chemistry: Used as a coupling agent and for the temporary protection of amine functionalities during solid-phase and solution-phase peptide synthesis.
• Agrochemical Production: Serves as a building block in the manufacture of advanced crop protection agents and herbicides.
• Polymer Chemistry: Employed in the synthesis of specialized polymers, including polycarbonates and polyurethanes, where it acts as a monomer or chain modifier.
• Chemical Research & Development: A valuable tool in medicinal chemistry and process development for creating novel chemical entities and optimizing synthetic routes.
• Dye and Pigment Manufacturing: Utilized in the synthesis of certain high-performance dyes and organic pigments.

Basic Information

Product Name	m-tert-Butylphenyl Chloroformate
CAS No.	49561-88-8
Molecular Formula	C11H13ClO2
Molecular Weight	212.67 g/mol
Synonyms	3-(tert-Butyl)phenyl chloroformate; 3-tert-Butylphenyl chlorocarbonate; m-(tert-Butyl)phenyl chloroformate; 1-Chlorocarbonyloxy-3-tert-butylbenzene; 3-tert-Butylphenyl carbonochloridate; Carbonochloridic acid, 3-(1,1-dimethylethyl)phenyl ester; (3-tert-Butylphenoxy)carbonyl chloride
EINECS	Contact for details

Quality Control

Our m-tert-Butylphenyl Chloroformate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.