Description

5-Methyl-4-Thiouridine is a modified nucleoside analog of significant interest in biochemical and pharmaceutical research. This compound serves as a critical building block and research tool for studying RNA structure, function, and post-transcriptional modifications. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleic acid chemistry, antiviral drug discovery, and molecular biology. The product is supplied to meet the stringent purity requirements of advanced life science applications.

Application

• Biochemical Research: Used as a substrate or intermediate in enzymatic studies related to tRNA modification and RNA metabolism.
• Antiviral Drug Discovery: Serves as a key synthetic precursor or analog in the development of novel nucleoside-based antiviral agents.
• RNA Structure Probing: Employed to investigate RNA folding, stability, and ligand interactions due to its unique thio-modification.
• Synthetic Biology: Incorporated into synthetic oligonucleotides to study the effects of specific nucleoside modifications on RNA function.
• Pharmaceutical Intermediates: Acts as a high-value intermediate in the multi-step synthesis of more complex therapeutic candidates.
• Academic Research: Utilized in university and institutional labs for fundamental studies in chemical biology and medicinal chemistry.

Basic Information

Product Name	5-Methyl-4-Thiouridine
CAS No.	49555-43-3
Molecular Formula	C10H14N2O5S
Molecular Weight	274.29 g/mol
Synonyms	4-Thio-5-methyluridine; 5-Methyl-4-thiouridine; 5-Methyl-4-thio-uridine; 4-Thiouridine, 5-methyl-; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methyl-2,4(1H,3H)-pyrimidinedithione; 5-Methyl-2,4-dithiouridine
EINECS	Contact for details

Quality Control

Our 5-Methyl-4-Thiouridine is produced under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic identification. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.