Description

5Beta-Cholanic Acid-3Alpha,7Alpha,12Alpha-Triol Ethyl Ester is a high-purity, synthetic bile acid derivative and a key intermediate in the production of ursodeoxycholic acid (UDCA) and other therapeutic bile acids. This compound is critical for pharmaceutical research and manufacturing, offering a defined stereochemistry essential for producing active pharmaceutical ingredients (APIs) with high biological specificity. It is primarily utilized by fine chemical manufacturers, pharmaceutical R&D laboratories, and CROs specializing in hepatology and metabolic disease treatments.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of ursodeoxycholic acid (UDCA), a primary medication for gallstone dissolution and primary biliary cholangitis.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for quality control and method validation in bile acid analysis.
• Biochemical Research: Employed in metabolic pathway studies, particularly research focused on cholesterol metabolism, bile acid synthesis, and liver function.
• API Development: Serves as a precursor in the development and scale-up of novel therapeutic bile acids and their conjugates for hepatobiliary diseases.
• Process Chemistry: Valued in process optimization and route scouting for the commercial production of high-value cholanic acid derivatives.

Basic Information

Item	Details
Product Name	5Beta-Cholanic Acid-3Alpha,7Alpha,12Alpha-Triol Ethyl Ester
CAS No.	47676-48-2
Molecular Formula	C₂₆H₄₄O₅
Molecular Weight	436.63 g/mol
Synonyms	Ethyl 3α,7α,12α-Trihydroxy-5β-cholan-24-oate; Ethyl 3α,7α,12α-Trihydroxy-5β-cholanate; Ethyl Cholate; 5β-Cholan-24-oic Acid, 3α,7α,12α-Trihydroxy-, Ethyl Ester; Ethyl 3,7,12-Trihydroxycholanate; Cholic Acid Ethyl Ester; Ethyl 3α,7α,12α-Trihydroxy-5β-cholanoate
EINECS	Contact for details

Quality Control

Our 5Beta-Cholanic Acid-3Alpha,7Alpha,12Alpha-Triol Ethyl Ester is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support audits for cGMP compliance where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.