Description

2'-O,3'-o-(4-Methoxybenzylidene)Adenosine is a chemically modified nucleoside derivative, primarily utilized as a key synthetic intermediate in advanced pharmaceutical research and development. Its value lies in its role as a versatile building block for the synthesis of novel nucleotide analogs and prodrugs, enabling the creation of compounds with enhanced biological activity and stability. This high-purity intermediate is essential for researchers and manufacturers in the fields of antiviral drug discovery, oncology therapeutics, and the development of next-generation oligonucleotide-based medicines.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel adenosine-based antiviral and anticancer agents.
• Nucleoside Chemistry Research: Used in academic and industrial R&D for studying nucleoside modifications, structure-activity relationships (SAR), and prodrug strategies.
• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase synthesis of modified RNA and DNA strands with specific functionalities.
• Prodrug Development: Employed in designing bioreversible derivatives of nucleoside drugs to improve bioavailability and targeting.
• Biochemical Tool Compound: Utilized in enzymatic studies to investigate the activity of kinases, polymerases, and other nucleoside-processing enzymes.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2'-O,3'-o-(4-Methoxybenzylidene)Adenosine
CAS No.	47578-96-1
Molecular Formula	C19H21N5O6
Molecular Weight	415.40 g/mol
Synonyms	4-Methoxybenzylidene Adenosine; 2',3'-O-(4-Methoxybenzylidene)adenosine; 2',3'-O-(p-Methoxybenzylidene)adenosine; Adenosine, 2',3'-O-(4-methoxybenzylidene)-; 2',3'-Isopropylideneadenosine analog; 2'-O,3'-O-[(4-Methoxyphenyl)methylene]adenosine; N6-Adenosine derivative, protected; 1-(6-Amino-9H-purin-9-yl)-1-deoxy-2,3-O-[(4-methoxyphenyl)methylene]-β-D-ribofuranose
EINECS	Contact for details

Quality Control

Our 2'-O,3'-o-(4-Methoxybenzylidene)Adenosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry guidelines for the production of fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.