Description

1,2-Cyclobutanedicarbonyl Dichloride, (1R-Trans)- (9Ci) is a high-purity, chiral building block of significant importance in advanced organic synthesis. This compound matters for its role as a key precursor in the synthesis of complex, stereochemically defined molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing constrained ring systems and chiral centers.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially those requiring a rigid, trans-cyclobutane backbone.
• Asymmetric Synthesis: Used in the construction of complex natural products and bioactive compounds where the (1R,2R) stereochemistry is essential for biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.
• Peptidomimetics and Conformationally Restricted Peptides: Incorporated into peptide analogs to induce specific secondary structures and enhance metabolic stability.
• Material Science Research: Employed in the synthesis of monomers for specialized polymers with unique thermal or mechanical properties.
• Agrochemical Synthesis: Used in the research phase for creating new chiral herbicides or fungicides with improved efficacy and selectivity.

Basic Information

Product Name	1,2-Cyclobutanedicarbonyl Dichloride, (1R-Trans)- (9Ci)
CAS No.	45775-91-5
Molecular Formula	C6H6Cl2O2
Molecular Weight	181.02 g/mol
Synonyms	(1R,2R)-1,2-Cyclobutanedicarbonyl Dichloride; (1R,2R)-Cyclobutane-1,2-dicarbonyl Dichloride; trans-(1R,2R)-Cyclobutane-1,2-dicarboxylic Acid Dichloride; (1R,2R)-1,2-Cyclobutanedicarboxylic Acid Dichloride; (1R,2R)-CBDA Dichloride; (R,R)-Cyclobutane-1,2-dicarbonyl Chloride; (1R,2R)-Cyclobutanedioyl Dichloride
EINECS	Contact for details

Quality Control

Our 1,2-Cyclobutanedicarbonyl Dichloride, (1R-Trans)- (9Ci) is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Recommended long-term storage temperature is 2-8°C. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.