Description

1,2-Cyclopropanedicarbonyl Dichloride, (1S-Trans)- (9Ci) is a high-purity, stereochemically defined chiral building block essential for advanced organic synthesis. Its value lies in its rigid cyclopropane ring and highly reactive acid chloride groups, which enable the efficient construction of complex molecular architectures with precise stereocontrol. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a constrained, three-membered ring structure to modulate biological activity and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides where the cyclopropane moiety can enhance potency and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for creating chiral ligands, organocatalysts, and metal-organic frameworks (MOFs) used in asymmetric catalysis.
• Polymer Chemistry: Employed as a monomer or cross-linking agent for producing specialty polymers with unique thermal and mechanical properties derived from the strained ring system.
• Chemical Biology Probes: Utilized to synthesize molecular probes and labeled compounds for studying enzyme mechanisms and biological pathways.
• Material Science Research: Acts as a building block for novel organic materials and liquid crystals, leveraging its rigid, directional geometry.

Basic Information

Product Name	1,2-Cyclopropanedicarbonyl Dichloride, (1S-Trans)- (9Ci)
CAS No.	45718-99-8
Molecular Formula	C5H4Cl2O2
Molecular Weight	166.99 g/mol
Synonyms	(1S,2S)-1,2-Cyclopropanedicarbonyl dichloride; (1S-trans)-Cyclopropane-1,2-dicarbonyl dichloride; trans-(1S,2S)-Cyclopropane-1,2-dicarboxylic acid dichloride; (1S,2S)-Cyclopropane-1,2-dicarboxylic Acid Dichloride; (1S,2S)-1,2-Cyclopropanedicarboxylic Acid Dichloride; (1S,2S)-Cyclopropane-1,2-dicarbonyl Chloride; (1S,2S)-1,2-Cyclopropanedicarbonyl Chloride
EINECS	Contact for details

Quality Control

Our 1,2-Cyclopropanedicarbonyl Dichloride, (1S-Trans)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.