Description

2-Benzylthioadenosine is a chemically modified nucleoside analog of significant interest in medicinal chemistry and biochemical research. This compound serves as a versatile building block and a key intermediate in the synthesis of novel adenosine receptor ligands and enzyme inhibitors. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and academic research institutions focused on nucleotide chemistry, signal transduction pathways, and drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential therapeutic agents targeting adenosine receptors (A1, A2A, A2B, A3).
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving S-adenosylhomocysteine hydrolase (SAHase) and other methyltransferase enzymes.
• Medicinal Chemistry: Serves as a scaffold for structure-activity relationship (SAR) studies to develop novel anti-inflammatory, cardioprotective, or neuroprotective compounds.
• Nucleotide Analog Development: Employed in creating modified nucleotides for probing RNA/DNA structure and function or for antiviral/anticancer drug discovery.
• Chemical Biology Probes: Useful for developing activity-based probes to study purinergic signaling and related cellular processes.

Basic Information

Product Name	2-Benzylthioadenosine
CAS No.	43157-48-8
Molecular Formula	C17H19N5O4S
Molecular Weight	389.43 g/mol
Synonyms	2-[(Phenylmethyl)thio]adenosine; 2-(Benzylthio)adenosine; 9-β-D-Ribofuranosyl-2-(benzylthio)adenine; Adenosine, 2-(benzylthio)-; 2-Benzylmercaptoadenosine; BTA; NSC 113943
EINECS	Contact for details

Quality Control

Our 2-Benzylthioadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.