Description

Cyclopropanecarbonyl Chloride,2-Phenyl-Cis(-)- CAS NO 42916-12-1 is a high-purity, chiral acyl chloride derivative characterized by its cis-configured phenyl-substituted cyclopropane ring. This compound serves as a critical chiral building block and reagent in advanced organic synthesis, enabling the introduction of the sterically defined and pharmacologically relevant 2-phenylcyclopropylcarbonyl moiety. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, chiral ligands, and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of central nervous system (CNS) drugs, enzyme inhibitors, and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides with specific stereochemical requirements.
• Chiral Ligand & Catalyst Preparation: Serves as a precursor for synthesizing novel chiral ligands used in asymmetric catalysis.
• Peptide Mimetics & Bio-conjugation: Employed to introduce the rigid, lipophilic cyclopropane scaffold into peptide backbones or for protein labeling studies.
• Material Science Research: Acts as a monomer or modifying agent in the synthesis of specialized polymers with unique thermal or mechanical properties.
• Academic & Contract Research: Essential reagent for methodological development in organic chemistry and for exploring new reaction pathways involving strained ring systems.

Basic Information

Item	Details
Product Name	Cyclopropanecarbonyl Chloride,2-Phenyl-Cis(-)- CAS NO 42916-12-1
CAS No.	42916-12-1
Molecular Formula	C10H9ClO
Molecular Weight	180.63 g/mol
Synonyms	(-)-(1S,2S)-2-Phenylcyclopropanecarbonyl Chloride; (1S,2S)-2-Phenylcyclopropanecarboxylic Acid Chloride; cis-2-Phenylcyclopropanecarbonyl Chloride; L-2-Phenylcyclopropanecarbonyl Chloride; (1S,2S)-rel-2-Phenylcyclopropanecarboxylic Acid Chloride; 2-Phenylcyclopropanecarboxylic acid chloride, cis-(-)-; (-)-trans-2-Phenylcyclopropanecarbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of Cyclopropanecarbonyl Chloride,2-Phenyl-Cis(-)- is manufactured and tested under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results for identity, purity (typically by chiral HPLC), and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and highly volatile; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition and moisture uptake. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.