Description

2'-Tosyladenosine is a key nucleoside derivative where the 2'-hydroxyl group of adenosine is selectively protected with a tosyl moiety. This modification is critical for controlling reactivity in complex synthetic pathways, particularly in the preparation of modified oligonucleotides and nucleotide analogs. It serves as a vital synthetic intermediate for pharmaceutical research and development, especially in the fields of antiviral and anticancer drug discovery. Researchers and manufacturers in fine chemical synthesis and life science reagent production rely on its consistent quality for advanced molecular construction.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel nucleoside-based therapeutics, including potential antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used in the controlled synthesis of modified RNA and DNA strands, where the 2'-O-tosyl group acts as a protective group or a leaving group for further functionalization.
• Biochemical Research: Employed in studies investigating enzyme mechanisms, such as those of ribonucleases, or in the development of activity-based probes.
• Prodrug Development: Serves as a precursor in designing prodrugs of adenosine analogs to improve bioavailability and targeting.
• Glycosylation Chemistry: Acts as a glycosyl donor or acceptor in stereoselective glycosylation reactions to create complex nucleoside architectures.
• Labeled Compound Synthesis: A starting material for the preparation of isotopically labeled (e.g., 13C, 15N) adenosine derivatives for metabolic tracing and NMR studies.

Basic Information

Product Name	2'-Tosyladenosine
CAS No.	42776-78-3
Molecular Formula	C17H19N5O6S
Molecular Weight	421.43 g/mol
Synonyms	2'-O-Tosyladenosine; Adenosine, 2'-(4-methylbenzenesulfonate); 9-β-D-Ribofuranosyladenine 2'-(p-toluenesulfonate); 2'-O-(p-Tolylsulfonyl)adenosine; 2'-Tosyl-adenosine; 2'-OTs Adenosine; 2'-O-Ts-Ado
EINECS	Contact for details

Quality Control

Every batch of 2'-Tosyladenosine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (HPLC), identity (IR, NMR), and impurity profiles. Our quality commitment supports compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.