Description

5-Chlorothiophene-2-Carbonyl Chloride is a high-purity, reactive organosulfur building block essential for advanced chemical synthesis. Its bifunctional nature, featuring both an acid chloride and a halogenated heterocycle, makes it a critical intermediate for constructing complex molecular architectures with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system and anti-inflammatory applications.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides, leveraging the thiophene moiety for enhanced biological activity.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent for producing specialty polymers, conductive materials, and liquid crystals.
• Organic Synthesis Building Block: Employed in amide coupling and nucleophilic substitution reactions to introduce the 5-chlorothiophene-2-carbonyl moiety into more complex molecules.
• Dye & Pigment Manufacturing: Intermediate for synthesizing specialized heterocyclic dyes and organic pigments.
• Research & Development: Vital reagent in medicinal chemistry and process development for scale-up and route optimization.

Basic Information

Product Name	5-Chlorothiophene-2-Carbonyl Chloride
CAS No.	42518-98-9
Molecular Formula	C5H2Cl2OS
Molecular Weight	181.04 g/mol
Synonyms	2-Chlorocarbonyl-5-chlorothiophene; 5-Chloro-2-thiophenecarbonyl chloride; 5-Chlorothiophene-2-carboxylic acid chloride; 2,5-Dichlorothiophene-2-carboxaldehyde (misnomer); 5-Chlorothienyl-2-carbonyl chloride; 5-Chloro-2-thienoyl chloride; 5-Chlorothiophene-2-carbonylchloride
EINECS	Contact for details

Quality Control

Our 5-Chlorothiophene-2-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.