Description

Acivicin CAS NO 42228-92-2 is a potent and selective glutamine antagonist, functioning as an irreversible inhibitor of several glutamine-utilizing enzymes. This mechanism of action makes it a critical research tool for studying cellular metabolism, signal transduction, and the role of glutamine in disease progression. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, metabolic disorder, and enzymology research.

Application

• Biochemical Research: Used as a specific inhibitor to study glutamine metabolism pathways and their role in cellular function.
• Oncology Research: Investigated for its potential anti-tumor properties by targeting the altered metabolism of cancer cells (glutaminolysis).
• Enzymology Studies: Serves as a tool compound for the characterization of enzymes such as glutaminase, carbamoyl phosphate synthetase, and CTP synthetase.
• Metabolic Disorder Research: Applied in models to understand diseases where glutamine metabolism is dysregulated.
• Cell Culture & In Vitro Assays: Used to modulate glutamine availability and study its effects on cell proliferation, differentiation, and survival.
• Pharmaceutical Reference Standard: Employed as a high-purity analytical standard for method development and quality control in drug discovery pipelines.

Basic Information

Product Name	Acivicin
CAS No.	42228-92-2
Molecular Formula	C5H7ClN2O3
Molecular Weight	178.57 g/mol
Synonyms	AT-125; L-(αS,5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid; NSC 163501; U-42126; Acivicin; CI-919; Antibiotic U-42126; (αS,5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic Acid
EINECS	Contact for details

Quality Control

Our Acivicin is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals to guarantee reliable and reproducible results for your scientific work.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, well-ventilated area. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.