Description

3'-Amino-3'-Deoxythymidine 5'-Monophosphate is a modified nucleotide monophosphate derivative of thymidine, where the 3'-hydroxyl group is replaced by an amino moiety. This structural modification makes it a valuable intermediate and building block in the synthesis of oligonucleotides, particularly for research into antisense therapeutics, diagnostic probes, and other nucleic acid-based technologies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for advanced molecular biology applications.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides designed to target specific mRNA sequences.
• Diagnostic Probe Manufacturing: Incorporated into nucleic acid probes for assays, hybridization, and diagnostic kits to enhance specificity or stability.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to investigate polymerase and nuclease activities.
• Pharmaceutical Intermediates: Acts as a critical building block in the development of novel nucleotide-based therapeutics.

Basic Information

Product Name	3'-Amino-3'-Deoxythymidine 5'-Monophosphate
CAS No.	42214-32-4
Molecular Formula	C10H16N3O7P
Molecular Weight	321.23 g/mol
Synonyms	3'-Amino-3'-deoxythymidine 5'-phosphate; 3'-Amino-2',3'-dideoxythymidine 5'-monophosphate; 5'-TMP-3'-NH2; dT-3'-NH2-5'-MP; 1-[(2R,4S,5R)-4-Amino-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 5'-phosphate; 3'-Amino-3'-deoxy-5'-TMP; 3'-Amino-ddTMP
EINECS	Contact for details

Quality Control

Our 3'-Amino-3'-Deoxythymidine 5'-Monophosphate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.