Description

5'-Azido-5'-Deoxyguanosine is a chemically modified nucleoside analog featuring an azido group at the 5'-position of the deoxyribose sugar. This compound is a critical building block and versatile intermediate in the synthesis of oligonucleotide probes and therapeutic agents, particularly for click chemistry applications. It is essential for researchers and manufacturers in the fields of nucleic acid chemistry, medicinal chemistry, and bioconjugation, enabling the development of targeted diagnostics and novel pharmaceuticals.

Application

• Click Chemistry Reagent: Acts as a key substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to label or functionalize oligonucleotides.
• Oligonucleotide Synthesis: Serves as a modified phosphoramidite or solid-support precursor for incorporating azide handles into DNA or RNA strands.
• Bioconjugation & Probe Development: Used to create fluorescent, affinity, or therapeutic probes for imaging, diagnostics, and targeted drug delivery systems.
• Medicinal Chemistry Research: Employed in the synthesis of nucleoside-based prodrugs and antiviral/anticancer candidate molecules.
• Chemical Biology Tools: Facilitates the study of nucleic acid-protein interactions and metabolic pathways through site-specific labeling.
• Material Science: Used in the development of functionalized surfaces and nanomaterials for biosensing applications.

Basic Information

Product Name	5'-Azido-5'-Deoxyguanosine
CAS No.	42204-44-4
Molecular Formula	C10H12N8O4
Molecular Weight	308.26 g/mol
Synonyms	5'-Azido-2'-deoxyguanosine; 5'-Azido-5'-deoxy-2'-deoxyguanosine; 9-[(5-Azido-5-deoxy-β-D-erythro-pentofuranosyl)]guanine; 5'-N3-dG; Azido-dG; Guanosine, 5'-azido-5'-deoxy-; 5'-Deoxy-5'-azidoguanosine
EINECS	Contact for details

Quality Control

Our 5'-Azido-5'-Deoxyguanosine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.