Description

2',3'-Di-o-Acetylguanosine is a key protected nucleoside derivative, specifically an acetylated form of guanosine. This chemical modification is crucial for enhancing stability and controlling reactivity during complex synthetic processes, particularly in oligonucleotide synthesis. It serves as a vital building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the development of nucleic acid-based therapeutics and diagnostic probes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used as a protected monomer in solid-phase and solution-phase synthesis of DNA and RNA sequences for research and therapeutic applications.
• Biochemical Research: Employed in studies of nucleic acid structure, function, and enzyme mechanisms where a modified guanosine base is required.
• Prodrug Development: Acts as a masked form of guanosine for designing prodrugs with improved bioavailability and targeted delivery.
• Reference Standard: Serves as a high-purity analytical standard for quality control in pharmaceutical manufacturing and research laboratories.

Basic Information

Product Name	2',3'-Di-o-Acetylguanosine
CAS No.	42167-65-7
Molecular Formula	C₁₄H₁₇N₅O₇
Molecular Weight	367.32 g/mol
Synonyms	2',3'-Di-O-acetylguanosine; Guanosine, 2',3'-diacetate; 9-[(2R,3R,4R,5R)-3,4-Diacetoxy-5-(hydroxymethyl)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one; NSC 401005; 2',3'-Diacetyl Guanosine; 2',3'-O-Diacetylguanosine; Guanosine 2',3'-diacetate
EINECS	Contact for details

Quality Control

Our 2',3'-Di-o-Acetylguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container should be kept tightly sealed in a desiccated environment to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.