Description

2-Chlorotrityl Chloride is a highly versatile and reactive protecting group reagent extensively used in solid-phase peptide synthesis (SPPS). Its primary value lies in its ability to anchor amino acids to resin with exceptional acid lability, allowing for mild cleavage conditions that preserve sensitive peptide sequences. This makes it an indispensable tool for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing complex peptides, oligonucleotides, and other fine chemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): As the preferred linker for anchoring the first amino acid to polymeric resin, enabling the synthesis of peptide acids.
• Oligonucleotide Synthesis: Used as a solid support for the preparation of DNA/RNA fragments and their analogs.
• Combinatorial Chemistry: Facilitates the generation of diverse chemical libraries for drug discovery and high-throughput screening.
• Protecting Group Chemistry: Serves as a robust protecting group for carboxylic acids and alcohols in multi-step organic synthesis.
• Pharmaceutical Intermediate: A key building block in the research and production of active pharmaceutical ingredients (APIs), particularly peptide-based therapeutics.
• Glycopeptide Synthesis: Enables the synthesis of complex glycopeptides by providing a stable yet cleavable anchor point on solid support.

Basic Information

Product Name	2-Chlorotrityl Chloride
CAS No.	42074-68-0
Molecular Formula	C20H14Cl2
Molecular Weight	325.23 g/mol
Synonyms	2-Chlorotrityl Chloride; 2-Chloro-α,α-diphenylbenzyl Chloride; (2-Chlorophenyl)diphenylmethyl Chloride; CTC Chloride; CTC Resin Linker; 2-Chlorotriphenylmethyl Chloride; NSC 334369; Chloro(2-chlorophenyl)diphenylmethane
EINECS	255-652-5

Quality Control

Our 2-Chlorotrityl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.