Description

(2S,4Aβ,10Aα)-7α-(Acetyloxy)-3,4,4A,4B,5,6,7,8,8A,9,10,10A-Dodecahydro-8Aβ-Hydroxy-2β,4Bα-Dimethyl-1(2H)-Phenanthrenone is a high-purity, complex diterpenoid derivative with a defined stereochemistry, making it a valuable advanced pharmaceutical intermediate for research and synthesis. Its intricate structure serves as a critical building block for developing novel therapeutic agents, particularly in the fields of oncology and anti-inflammatory drug discovery. This compound is essential for pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex natural product analogs and targeted small molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and natural product derivatives.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic compounds.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Organic Synthesis: Employed in academic and industrial research for exploring novel synthetic pathways and catalytic transformations of diterpenoid frameworks.
• Biochemical Research: Potential use as a probe or inhibitor in studying specific enzymatic pathways or biological targets.

Basic Information

Product Name	(2S,4Aβ,10Aα)-7α-(Acetyloxy)-3,4,4A,4B,5,6,7,8,8A,9,10,10A-Dodecahydro-8Aβ-Hydroxy-2β,4Bα-Dimethyl-1(2H)-Phenanthrenone
CAS No.	41853-21-8
Molecular Formula	C20H30O4
Molecular Weight	334.45 g/mol
Synonyms	7α-Acetoxy-8aβ-hydroxy-2β,4bα-dimethyldodecahydrophenanthren-1-one; 7α-Acetoxy-8aβ-hydroxy-2β,4bα-dimethylperhydrophenanthren-1-one; 8aβ-Hydroxy-2β,4bα-dimethyl-7α-acetoxyperhydrophenanthren-1-one; 7α-Acetoxy-8aβ-hydroxy-2β,4bα-dimethyldodecahydro-1-phenanthrone; A derivative of Totarol; Diterpenoid intermediate
EINECS	Contact for details

Quality Control

Our (2S,4Aβ,10Aα)-7α-(Acetyloxy)-3,4,4A,4B,5,6,7,8,8A,9,10,10A-Dodecahydro-8Aβ-Hydroxy-2β,4Bα-Dimethyl-1(2H)-Phenanthrenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.