Description

4-Piperidinecarbonyl Chloride, 1-Methyl- (9Ci) is a versatile and highly reactive organic intermediate, primarily used as a key building block in sophisticated chemical synthesis. Its value lies in its ability to efficiently introduce the 1-methylpiperidine-4-carbonyl moiety, a crucial structural motif in modern pharmaceuticals and agrochemicals. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity, reliable intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) agents, receptor antagonists, and enzyme inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the piperidine scaffold contributes to biological activity.
• Fine Chemical Production: Serves as a precursor for various specialty chemicals, dyes, and functional materials requiring the 1-methylpiperidine structure.
• Research & Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new drug candidates.
• Peptide Mimetics & Bioconjugation: The acid chloride functionality makes it suitable for creating peptide analogs and for bioconjugation strategies in chemical biology.

Basic Information

Product Name	4-Piperidinecarbonyl Chloride, 1-Methyl- (9Ci)
CAS No.	41776-24-3
Molecular Formula	C7H12ClNO
Molecular Weight	161.63 g/mol
Synonyms	1-Methylpiperidine-4-carbonyl chloride; 4-(Chlorocarbonyl)-1-methylpiperidine; N-Methylisonipecotyl chloride; 1-Methylisonipecotyl chloride; Isonipecotyl chloride, N-methyl-; 1-Methyl-4-piperidinecarbonyl chloride; 4-Carbamoyl-1-methylpiperidine hydrochloride (related); N-Methyl-4-piperidinecarbonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Piperidinecarbonyl Chloride, 1-Methyl- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We employ advanced analytical techniques including HPLC, GC, and NMR to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.