Description

1-Methyl-1H-Imidazole-5-Carbonyl Chloride is a high-purity, reactive acyl chloride derivative of a methylated imidazole, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile coupling reagent and intermediate for introducing the 1-methyl-1H-imidazole-5-carbonyl moiety into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing imidazole-based heterocycles.
• Agrochemical Synthesis: Used in the production of advanced fungicides, herbicides, and plant growth regulators.
• Ligand and Catalyst Precursor: Serves as a precursor for synthesizing specialized N-heterocyclic carbene (NHC) ligands and organocatalysts.
• Polymer Chemistry: Employed in the modification of polymers and the creation of functional materials with specific chemical properties.
• Peptide Mimetics & Bioconjugation: Useful for creating peptide analogs and for bioconjugation strategies in medicinal chemistry and chemical biology.
• Research & Development: A valuable reagent for academic and industrial R&D in novel synthetic methodologies and compound library generation.

Basic Information

Product Name	1-Methyl-1H-Imidazole-5-Carbonyl Chloride
CAS No.	41716-12-5
Molecular Formula	C5H5ClN2O
Molecular Weight	144.56 g/mol
Synonyms	1-Methyl-1H-imidazole-5-carbonyl chloride; 1-Methylimidazole-5-carbonyl chloride; 5-(Chlorocarbonyl)-1-methylimidazole; 1-Methyl-5-imidazolecarbonyl chloride; 1-Methyl-1H-imidazole-5-carboxylic acid chloride; 1-Methylimidazole-5-carboxylic acid chloride; 41716-12-5
EINECS	Contact for details

Quality Control

Our 1-Methyl-1H-Imidazole-5-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.