Description

(3R)-3,4,5,6-Tetrahydro-11-Methyl-4α-[(Trimethylsilyl)Oxy]-3β,6β-Epoxy-2H,8H-Pyrimido[6,1-B][1,3]Oxazocine-8,10(9H)-Dione is a complex, high-purity organic compound featuring a unique fused heterocyclic structure with a trimethylsilyl-protected hydroxyl group. This compound is a critical advanced pharmaceutical intermediate or building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in specialized therapeutic areas. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of complex molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting the central nervous system or with specific stereochemical requirements.
• Organic Synthesis Research: Used as a specialized building block in academic and industrial research for constructing novel heterocyclic frameworks and exploring new chemical spaces.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for new chemical entities (NCEs) during preclinical and early-phase clinical development.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Asymmetric Synthesis: Its defined stereochemistry makes it valuable for studies in asymmetric catalysis and the preparation of enantiomerically pure compounds.

Basic Information

Item	Details
Product Name	(3R)-3,4,5,6-Tetrahydro-11-Methyl-4α-[(Trimethylsilyl)Oxy]-3β,6β-Epoxy-2H,8H-Pyrimido[6,1-B][1,3]Oxazocine-8,10(9H)-Dione
CAS No.	41547-76-6
Molecular Formula	C16H24N2O5Si
Molecular Weight	352.46 g/mol
Synonyms	11-Methyl-4α-[(trimethylsilyl)oxy]-3β,6β-epoxy-3,4,5,6-tetrahydro-2H,8H-pyrimido[6,1-b][1,3]oxazocine-8,10(9H)-dione; (3R)-3,4,5,6-Tetrahydro-11-methyl-4α-[(trimethylsilyl)oxy]-3β,6β-epoxy-2H,8H-pyrimido[6,1-b][1,3]oxazocine-8,10(9H)-dione; CAS 41547-76-6; TMS-protected epoxy oxazocine dione; Pyrimidooxazocine dione derivative.
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to stringent quality protocols suitable for pharmaceutical research. Every batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing key parameters such as assay (by HPLC), chiral purity, and impurity profiles. We support development with custom synthesis and scale-up services under quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.