Description

3,3,3-Trifluoropropionyl Chloride is a high-purity fluorinated building block essential for introducing the trifluoropropionyl moiety into complex molecules. Its primary value lies in enabling the synthesis of advanced agrochemicals and pharmaceuticals with enhanced metabolic stability and bioavailability. This reagent is critically needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediates: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated side chains to modulate lipophilicity and metabolic profile.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoropropionyl group contributes to efficacy and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated compounds used in electronic displays and optical devices.
• Polymer Modification: Employed to introduce fluorine-containing functional groups into polymer chains, altering surface properties and chemical resistance.
• Organic Synthesis Reagent: A versatile acylating agent for amide and ester formation in complex multi-step synthetic routes under controlled conditions.
• Advanced Material Research: Used in R&D for developing new fluorinated materials with unique electronic or surface characteristics.

Basic Information

Product Name	3,3,3-Trifluoropropionyl Chloride
CAS No.	41463-83-6
Molecular Formula	C3H2ClF3O
Molecular Weight	146.49 g/mol
Synonyms	3,3,3-Trifluoropropanoyl Chloride; Trifluoropropionyl Chloride; 3,3,3-Trifluoropropionic Acid Chloride; Perfluoropropionyl Chloride (common name); TFPC; Propionyl chloride, 3,3,3-trifluoro-; NSC 9235; EINECS 255-386-8
EINECS	255-386-8

Quality Control

Our 3,3,3-Trifluoropropionyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including GC, NMR, and titration to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing all test results are provided with each shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 0.5%
Density (at 20°C)	1.40 - 1.45 g/mL
Boiling Point	Approx. 70-72°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.