Description

α-Methyldopa Sesquihydrate is a pharmaceutical active ingredient and a key synthetic intermediate, primarily known for its role as an antihypertensive agent. Its value lies in its specific stereochemistry and high purity, which are critical for ensuring the efficacy and safety of final drug formulations. This compound is essential for manufacturers in the pharmaceutical industry, particularly those developing and producing cardiovascular medications, as well as for research institutions conducting pharmacological studies.

Application

• Active Pharmaceutical Ingredient (API): Primary use as the active component in antihypertensive medications.
• Pharmaceutical Intermediates: Serves as a crucial building block in the synthesis of more complex drug molecules.
• Reference Standard: Used in analytical laboratories for quality control, method development, and calibration in HPLC and other chromatographic systems.
• Biochemical Research: Employed in pharmacological and metabolic studies to investigate mechanisms of action related to blood pressure regulation.
• Formulation Development: Utilized in pre-formulation and formulation studies for solid dosage forms like tablets and capsules.

Basic Information

Product Name	α-Methyldopa Sesquihydrate
CAS No.	41372-08-1
Molecular Formula	C10H13NO4 · 1½H2O
Molecular Weight	238.23 g/mol (Anhydrous basis)
Synonyms	L-α-Methyldopa Sesquihydrate; (-)-α-Methyldopa Sesquihydrate; (S)-3-(3,4-Dihydroxyphenyl)-2-methylalanine Sesquihydrate; Methyldopa Sesquihydrate; Aldomet Intermediate; L-MDOPA Sesquihydrate; 2-Methyl-3-(3,4-dihydroxyphenyl)-L-alanine Sesquihydrate; MK-351 Sesquihydrate
EINECS	Contact for details

Quality Control

Our α-Methyldopa Sesquihydrate is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with specifications aligning with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	10.0% - 13.0% (Theoretical for Sesquihydrate: ~11.3%)
Specific Rotation	-25° to -30° (c = 1 in 1N HCl)
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.