Description

5-Thiazolecarbonyl Chloride (9Ci) is a versatile and highly reactive acyl chloride derivative of the thiazole heterocycle. This compound serves as a critical building block for the synthesis of more complex molecules, enabling the introduction of the 5-thiazolecarbonyl moiety into target structures. It is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and advanced intermediates. The compound, identified by CAS NO 41125-73-9, is essential for medicinal chemistry programs and the development of specialty chemicals.

Application

• Pharmaceutical Intermediate: Key reagent for synthesizing thiazole-containing drug candidates, including potential kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with thiazole cores.
• Material Science Research: Used in the development of organic semiconductors, ligands for catalysis, and functional polymers.
• Peptide & Protein Modification: Acylating agent for modifying amino acid side chains or introducing thiazole-based fluorescent probes.
• Chemical Biology: Tool compound for activity-based protein profiling (ABPP) and probe development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific advanced intermediates.

Basic Information

Product Name	5-Thiazolecarbonyl Chloride (9Ci)
CAS No.	41125-73-9
Molecular Formula	C4H2ClNOS
Molecular Weight	147.58 g/mol
Synonyms	Thiazole-5-carbonyl chloride; 5-Carboxythiazole chloride; 1,3-Thiazole-5-carbonyl chloride; 5-Thiazolylcarbonyl chloride; 5-Thiazolecarboxylic acid chloride; Thiazolecarbonyl chloride; 5-Thiazole carbonyl chloride; 5-Thiazole carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 5-Thiazolecarbonyl Chloride is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets exacting standards for research and industrial use. We provide full traceability and batch-specific Certificates of Analysis (COA) upon request, guaranteeing consistency and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.