Description

5'-Trt-N4-Bz-Rc is a protected nucleoside derivative, specifically a ribocytidine analog, widely used as a critical building block in oligonucleotide synthesis. Its primary value lies in enabling the precise and efficient construction of RNA sequences for research and therapeutic development. This high-purity intermediate is essential for pharmaceutical R&D, biotechnology companies, and academic institutions focused on antisense technology, siRNA, and mRNA applications.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A key phosphoramidite precursor for the automated synthesis of RNA strands.
• Antisense Oligonucleotide (ASO) Development: Used in the research and production of therapeutic ASOs targeting genetic diseases.
• siRNA and miRNA Synthesis: Serves as a protected monomer for constructing short interfering RNA (siRNA) and microRNA (miRNA) molecules.
• mRNA Vaccine and Therapeutic Production: A vital raw material in the synthesis of modified mRNA constructs.
• Diagnostic Probe Development: Employed in creating labeled RNA probes for diagnostic assays and genomic research.
• Medicinal Chemistry & Nucleoside Analogue Research: Used as a scaffold for developing novel nucleoside-based pharmaceuticals.

Basic Information

Product Name	5'-Trt-N4-Bz-Rc
CAS No.	41092-41-5
Molecular Formula	C32H31N3O5
Molecular Weight	537.61 g/mol
Synonyms	5'-O-Trityl-N4-benzoylcytidine; 1-[(2R,3R,4R,5R)-5-[(4-Benzamido-2-oxopyrimidin-1-yl)]-3,4-dihydroxyoxolan-2-yl]methoxy-triphenylmethane; N4-Benzoyl-5'-O-tritylcytidine; N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-tritylcytidine (related protected form); 5'-O-(Triphenylmethyl)-N4-benzoylcytidine; Protected Cytidine Phosphoramidite Building Block; Trt-C(Bz) Ribonucleoside
EINECS	Contact for details

Quality Control

Our 5'-Trt-N4-Bz-Rc is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to GMP principles for pharmaceutical intermediates, and our quality protocols are designed to meet the stringent requirements of FDA-filed drug applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.