Description

(17α,20S)-5α-Cholestane-3β,6α-Diol is a high-purity steroidal diol derivative, serving as a critical intermediate and reference standard in advanced pharmaceutical and biochemical research. Its defined stereochemistry makes it an invaluable tool for studying steroid metabolism, enzyme mechanisms, and for the synthesis of more complex bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors requiring precise chemical building blocks for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and novel drug candidates.
• Biochemical Research: Used as a reference standard and substrate in enzymatic studies, particularly for investigating hydroxysteroid dehydrogenases and other metabolic pathways.
• Metabolite Standard: Critical for analytical method development and validation in LC-MS/MS and HPLC assays for quantifying steroid metabolites in biological samples.
• Fine Chemical Synthesis: Employed in the preparation of specialized steroidal probes, ligands, and other high-value fine chemicals for research applications.
• Quality Control: Serves as a certified reference material (CRM) for the quality assurance and purity testing of related steroid compounds in manufacturing.

Basic Information

Product Name	(17α,20S)-5α-Cholestane-3β,6α-Diol
CAS No.	41083-77-6
Molecular Formula	C27H48O2
Molecular Weight	404.67 g/mol
Synonyms	5α-Cholestane-3β,6α-diol, (3β,5α,6α)-; 3β,6α-Dihydroxy-5α-cholestane; (17α,20S)-Cholestane-3β,6α-diol; NSC 163063; 3β,6α-Dihydroxycholestane; 5α-Cholestan-3β-ol-6α-ol
EINECS	Contact for details

Quality Control

Our (17α,20S)-5α-Cholestane-3β,6α-Diol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods (IR, NMR). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% de
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.