Description

Amphotericin B, Tetradecahydro- is a hydrogenated derivative of the well-known polyene macrolide antifungal agent, Amphotericin B. This chemical modification is designed to alter the compound's pharmacological profile, potentially reducing toxicity while retaining or modifying biological activity. It serves as a critical pharmaceutical intermediate and reference standard in the research and development of novel antifungal therapies. This compound is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) focused on infectious disease treatments.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel, hydrogenated Amphotericin B analogs with potentially improved safety profiles.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related pharmaceutical products and impurities.
• Biomedical Research: Employed in in vitro and in vivo studies to investigate the structure-activity relationship (SAR) of polyene antibiotics and their mechanisms of action against fungal pathogens.
• API Development: Integral to the research phase for developing new antifungal active pharmaceutical ingredients with modified pharmacokinetic and pharmacodynamic properties.
• Impurity Profiling: Acts as a specified impurity or degradation product standard for the analysis of Amphotericin B drug substances and finished dosage forms.

Basic Information

Product Name	Amphotericin B, Tetradecahydro-
CAS No.	40904-73-2
Molecular Formula	C47H73NO17
Molecular Weight	924.08 g/mol
Synonyms	Dihydroamphotericin B (Hydrogenated); Tetradecahydroamphotericin B; Amphotericin B Hydrogenated; 28,29-Dihydroamphotericin B; Amphotericin B (reduced); Amphotericin B, hydrogenated derivative; NSC 527985
EINECS	Contact for details

Quality Control

Our Amphotericin B, Tetradecahydro- is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, spectroscopic identification (IR, NMR), and tests for residual solvents and moisture content. We provide full traceability and documentation. A detailed Certificate of Analysis (COA) is supplied with every shipment, ensuring compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.