Description

(+/-)-1-Methoxy-1-(Trifluoromethyl)Phenylacetyl Chloride CAS NO 40793-68-8 is a versatile chiral building block and acylating agent, characterized by its reactive acid chloride group and trifluoromethyl moiety. This compound is essential for introducing the α-methoxy-α-(trifluoromethyl)phenylacetyl (MTPA) group, a key chiral derivatizing agent used in determining enantiomeric purity. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the synthesis of advanced intermediates, chiral auxiliaries, and analytical reagents.

Application

• Chiral Derivatizing Agent: Critical for NMR spectroscopy to determine the enantiomeric excess (ee) of chiral alcohols and amines via Mosher's ester/amide formation.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and complex molecules requiring chiral resolution.
• Agrochemical Synthesis: Serves as a key intermediate in creating chiral pesticides and herbicides with enhanced biological activity.
• Asymmetric Synthesis: Acts as a chiral auxiliary or reagent in stereoselective chemical transformations.
• Analytical Chemistry: Employed in high-performance liquid chromatography (HPLC) for chiral separation and analysis.
• Material Science Research: Used in the development of specialty polymers and advanced organic materials with specific optical properties.

Basic Information

Product Name	(+/-)-1-Methoxy-1-(Trifluoromethyl)Phenylacetyl Chloride
CAS No.	40793-68-8
Molecular Formula	C11H10ClF3O2
Molecular Weight	266.64 g/mol
Synonyms	α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride; MTPA-Cl; Mosher's acid chloride; (±)-MTPA chloride; 2-Methoxy-2-(trifluoromethyl)-2-phenylacetyl chloride; 2-Methoxy-2-(trifluoromethyl)phenacetyl chloride; DL-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride
EINECS	Contact for details

Quality Control

Our production of (+/-)-1-Methoxy-1-(Trifluoromethyl)Phenylacetyl Chloride adheres to stringent internal quality protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is analyzed using advanced techniques including NMR, HPLC, and titration to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.