Description

Adenosine 3',5'-Monophosphodimethylamidate is a chemically modified nucleotide analog, specifically a dimethylamidate derivative of cyclic adenosine monophosphate (cAMP). This compound is of significant value in biochemical and pharmacological research as a stable, cell-permeable analog that mimics or modulates the activity of endogenous cAMP, a crucial secondary messenger. It is primarily needed by researchers and developers in the fields of signal transduction studies, drug discovery, and metabolic pathway analysis.

Application

• Biochemical Research: Used as a tool compound to study cAMP-dependent protein kinase (PKA) pathways and other cAMP-mediated signaling cascades in cell-based assays.
• Pharmaceutical Development: Serves as a reference standard or an intermediate in the synthesis of novel therapeutic agents targeting G-protein-coupled receptors (GPCRs).
• Cell Biology Studies: Employed to investigate the role of cAMP in cellular processes such as gene expression, ion channel function, and metabolism.
• Enzyme Inhibition/Activation Studies: Acts as a modulator for enzymes like phosphodiesterases (PDEs) to understand their regulatory mechanisms.
• Academic Research: A key reagent in university and institutional labs for fundamental research in molecular biology and physiology.
• Diagnostic Reagent Manufacturing: Potential use as a component in the development of diagnostic kits for research purposes.

Basic Information

Product Name	Adenosine 3',5'-Monophosphodimethylamidate
CAS No.	40732-50-1
Molecular Formula	C12H17N6O5P
Molecular Weight	356.28 g/mol
Synonyms	N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate dimethylamidate; cAMP dimethylamidate; Adenosine cyclic 3',5'-(hydrogen phosphate) dimethylamidate; N6,2'-O-Dibutyryl-cAMP dimethylamidate; Cyclic AMP dimethylamidate; 3',5'-Cyclic AMP dimethylamidate; DB-cAMP dimethylamidate; Research Grade cAMP analog
EINECS	Contact for details

Quality Control

Our Adenosine 3',5'-Monophosphodimidate is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture content. We provide Certificates of Analysis (COA) with every shipment, detailing all test results to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.