Description

Guanosine 3':5'-Cyclic Monophosphate Sodium Salt is a high-purity biochemical reagent essential for cellular signaling research. This compound serves as a critical second messenger, mediating the physiological effects of hormones and neurotransmitters in biological systems. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers for studying cyclic nucleotide-dependent pathways, enzyme kinetics, and cell regulation mechanisms.

Application

• Biochemical Research: Fundamental studies on intracellular signal transduction, protein kinase G (PKG) activation, and ion channel regulation.
• Pharmaceutical Development: Used as a reference standard and key intermediate in drug discovery programs targeting cardiovascular and neurological diseases.
• Diagnostic Assays: A vital component in enzyme immunoassays (EIAs) and radioimmunoassays (RIAs) for the quantitative detection of cGMP levels.
• Cell Culture & Physiology: Applied in cell-based assays to investigate the role of the cGMP pathway in smooth muscle relaxation, platelet aggregation, and visual phototransduction.
• Enzyme Substrate: Serves as a specific substrate for phosphodiesterases (PDEs) in enzymatic activity studies and inhibitor screening.

Basic Information

Product Name	Guanosine 3':5'-Cyclic Monophosphate Sodium Salt
CAS No.	40732-48-7
Molecular Formula	C10H11N5Na2O7P · xH2O
Molecular Weight	409.17 (Anhydrous)
Synonyms	cGMP Sodium Salt; Cyclic GMP Sodium Salt; Guanosine Cyclic 3',5'-(Hydrogen Phosphate) Sodium Salt; 3',5'-Cyclic GMP Na2; Sodium Guanosine 3',5'-Cyclic Monophosphate; 3',5'-cGMP Na2; cGMP-Na2; Guanosine 3',5'-cyclic monophosphate sodium salt hydrate
EINECS	Contact for details

Quality Control

Our Guanosine 3':5'-Cyclic Monophosphate Sodium Salt is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals to support your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0
Endotoxin	< 10 EU/mg
Biological Activity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.