Description

Thymidine 3'-Monophosphate Ammonium Salt is a high-purity nucleotide monophosphate derivative, essential for biochemical research and pharmaceutical development. This compound serves as a critical building block and intermediate in the synthesis of oligonucleotides, modified nucleotides, and various nucleotide-based therapeutics. It is primarily utilized by researchers and manufacturers in the fields of molecular biology, diagnostics, and the production of active pharmaceutical ingredients (APIs).

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for solid-phase synthesis of DNA and RNA sequences.
• Biochemical Research: Used as a substrate or intermediate in enzymatic studies, metabolic pathway analysis, and nucleotide metabolism research.
• Pharmaceutical Intermediates: Serves as a critical building block in the development of antiviral and anticancer nucleotide analog drugs.
• Diagnostic Reagent Manufacturing: Incorporated into probes and primers for PCR, sequencing, and other molecular diagnostic applications.
• Enzyme Kinetics Studies: Employed to study the activity and inhibition of kinases, phosphatases, and other nucleotide-processing enzymes.
• Cell Culture Media Supplement: Used in specialized media formulations for studying nucleotide requirements in cell growth and metabolism.

Basic Information

Product Name	Thymidine 3'-Monophosphate Ammonium Salt
CAS No.	40705-89-3
Molecular Formula	C10H19N3O8P
Molecular Weight	340.25 g/mol
Synonyms	3'-TMP Ammonium Salt; Thymidine 3'-Phosphate Ammonium Salt; 2'-Deoxythymidine 3'-monophosphate ammonium salt; dTMP-3' Ammonium Salt; 5-Methyl-2'-deoxyuridine 3'-(dihydrogen phosphate) ammonium salt; Ammonium thymidylate (3'); TMP-3' NH4+ salt
EINECS	Contact for details

Quality Control

Our Thymidine 3'-Monophosphate Ammonium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to ensure compliance with research and cGMP-grade standards for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or desiccant after each use to maintain purity and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Bacterial Endotoxins	< 0.25 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.