Description

D-α-Aminophenylacetic Acid Chloride is a high-purity chiral building block essential for the synthesis of optically active pharmaceutical intermediates. This compound matters for its role in creating enantiomerically pure active pharmaceutical ingredients (APIs), where stereochemical integrity is critical for efficacy and safety. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing novel therapeutics and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of β-lactam antibiotics, including semi-synthetic penicillins and cephalosporins.
• Peptide Synthesis: Used as an activated derivative for the incorporation of D-phenylglycine analogs into peptide chains under mild conditions.
• Agrochemicals: Building block for the synthesis of chiral herbicides and pesticides with enhanced biological activity.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and auxiliaries used in stereoselective synthesis.
• Protease Inhibitor Development: Utilized in the research and manufacturing of enzyme inhibitors targeting specific proteases.
• Fine Chemical Synthesis: Intermediate for creating complex, high-value specialty chemicals with defined stereochemistry.

Basic Information

Product Name	D-α-Aminophenylacetic Acid Chloride
CAS No.	40647-89-0
Molecular Formula	C8H8ClNO
Molecular Weight	169.61 g/mol
Synonyms	(R)-2-Amino-2-phenylacetyl chloride; D-(-)-α-Aminophenylacetyl chloride; (R)-α-Aminophenylacetic acid chloride; D-Phenylglycine chloride; (R)-2-Phenylglycinoyl chloride; D-α-Phenylglycine acid chloride; (R)-Amino(phenyl)acetic acid chloride
EINECS	Contact for details

Quality Control

Our D-α-Aminophenylacetic Acid Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical-grade intermediates. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere. Due to its hygroscopic and moisture-sensitive nature, containers must be kept sealed and handled under dry conditions to prevent hydrolysis. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.