Description

1-Chlorocarbonyl-1-Methylethyl Acetate is a specialized organic ester and acylating agent of significant interest in advanced chemical synthesis. Its value lies in its bifunctional structure, serving as a versatile building block for introducing protected carboxylic acid and ketone functionalities. This compound is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring specific carbonyl or ester moieties.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where its reactive groups enable the creation of novel heterocyclic compounds.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers with tailored thermal or mechanical properties.
• Peptide & Protein Modification: Employed as an acylating agent for modifying amino acid side chains or protecting groups in peptide synthesis.
• Organic Synthesis Reagent: A versatile reagent in academic and industrial laboratories for Friedel-Crafts acylation and other carbonyl-based reactions.
• Material Science Research: Used in developing novel organic frameworks, coatings, and advanced materials with specific functional group density.

Basic Information

Item	Detail
Product Name	1-Chlorocarbonyl-1-Methylethyl Acetate
CAS No.	40635-66-3
Molecular Formula	C6H9ClO3
Molecular Weight	164.59 g/mol
Synonyms	Acetic Acid, 2-(Chloroformyl)-2-propyl Ester; 2-(Chloroformyl)-2-propyl Acetate; 1-Acetoxy-1-methylethyl Chloroformate; 2-Acetoxyisobutyryl Chloride; 2-Propyl Acetate, 2-(Chloroformyl)-; Isobutyryl Chloride, 2-Acetoxy-; α-Acetoxyisobutyryl Chloride
EINECS	Contact for details

Quality Control

Our production of 1-Chlorocarbonyl-1-Methylethyl Acetate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including assay by GC/HPLC and impurity profiling. A Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment. We support cGMP-compliant manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture ingress and decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Impurities (GC/HPLC)	≤ 2.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.