Description

7-Deaza-2,3-Dideoxyadenosine is a chemically modified nucleoside analog, serving as a critical building block and research tool in medicinal chemistry and biochemistry. Its unique deaza and dideoxy structure makes it valuable for probing enzyme mechanisms and developing novel therapeutic agents. This compound is primarily sought by research institutions and pharmaceutical companies engaged in antiviral drug discovery, nucleic acid research, and the synthesis of nucleotide-based probes.

Application

• Antiviral Research & Drug Development: Investigated as a potential chain terminator or inhibitor for viral polymerases (e.g., HIV Reverse Transcriptase) due to its dideoxy modification.
• Biochemical & Enzymology Studies: Used as a substrate analog to study the activity, specificity, and inhibition mechanisms of nucleoside/nucleotide-processing enzymes like kinases and polymerases.
• Nucleic Acid Chemistry: Serves as a specialized monomer for the solid-phase synthesis of modified oligonucleotides with altered base-pairing or stability properties.
• Medicinal Chemistry Intermediate: A key synthetic precursor for the development of more complex nucleoside-derived compounds with potential pharmacological activity.
• Diagnostic Probe Development: Can be incorporated into nucleic acid probes for research assays, leveraging its modified structure to alter hybridization characteristics.

Basic Information

Product Name	7-Deaza-2,3-Dideoxyadenosine
CAS No.	40627-30-3
Molecular Formula	C11H14N4O2
Molecular Weight	234.26 g/mol
Synonyms	7-Deaza-2',3'-Dideoxyadenosine; 2,3-Dideoxy-7-deazaadenosine; 4-Amino-1-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-pyrrolo[2,3-d]pyrimidine; 7-Deaza-ddA; DADDA; 1H-Pyrrolo[2,3-d]pyrimidin-4-amine, 1-((2R,5S)-5-(hydroxymethyl)tetrahydro-2-furanyl)-
EINECS	Contact for details

Quality Control

We supply 7-Deaza-2,3-Dideoxyadenosine in high-purity grades suitable for research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC are available upon request. We adhere to a robust quality management system to guarantee batch-to-batch consistency and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.