Description

Guanadrel is a synthetic guanidine derivative and adrenergic neuron blocking agent. This compound is primarily valued for its pharmacological activity as an antihypertensive agent, functioning by inhibiting norepinephrine release from sympathetic nerve endings. It is of significant interest to the pharmaceutical industry for research and development purposes, particularly in the study of cardiovascular therapeutics and autonomic nervous system modulation.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of active pharmaceutical ingredients (APIs) for antihypertensive medications.
• Research & Development: Used in preclinical and clinical research to study mechanisms of sympathetic nervous system inhibition and blood pressure regulation.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Biochemical Studies: Employed in biochemical assays to investigate adrenergic neurotransmission and receptor interactions.
• Academic Research: Utilized in university and institutional research projects focused on cardiovascular pharmacology and neuropharmacology.

Basic Information

Product Name	Guanadrel
CAS No.	40580-59-4
Molecular Formula	C10H19N5
Molecular Weight	209.30 g/mol
Synonyms	Guanadrel Sulfate; (1,4-Dioxaspiro[4.5]dec-2-ylmethyl)guanidine; 2-(1,4-Dioxaspiro[4.5]dec-2-ylmethyl)guanidine; Guanadrelum; CI-775; NSC-113019; 1-[(1,4-Dioxaspiro[4.5]dec-2-yl)methyl]guanidine
EINECS	254-970-2

Quality Control

Our Guanadrel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and other chromatographic techniques, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.