Description

Tetrahydro-2H-Pyran-4-Ylacetyl Chloride is a versatile and reactive acid chloride derivative used as a key building block in advanced organic synthesis. Its value lies in its ability to efficiently introduce the tetrahydro-2H-pyran-4-ylacetyl moiety, a valuable structural motif, into target molecules. This high-purity intermediate is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create novel compounds with specific biological or material properties.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the tetrahydropyran ring can enhance bioavailability and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the synthesis of monomers and polymers with unique properties for advanced materials.
• Peptide Mimetics and Bioconjugation: Useful for acylating amines in the creation of peptide analogs or for bioconjugation strategies in probe and drug delivery system development.
• Custom Synthesis and Contract Manufacturing: A high-demand reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Item	Detail
Product Name	Tetrahydro-2H-Pyran-4-Ylacetyl Chloride
CAS No.	40500-05-8
Molecular Formula	C7H11ClO2
Molecular Weight	162.62 g/mol
Synonyms	4-(Chloroformylmethyl)tetrahydropyran; Tetrahydro-2H-pyran-4-acetyl chloride; 4-(Chloroacetyl)tetrahydropyran; Tetrahydropyran-4-ylacetyl chloride; 2-(Tetrahydro-2H-pyran-4-yl)acetyl chloride; 4-(2-Chloro-2-oxoethyl)tetrahydro-2H-pyran; (Oxan-4-yl)acetyl chloride
EINECS	Contact for details

Quality Control

Our Tetrahydro-2H-Pyran-4-Ylacetyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay (by GC/HPLC), identity confirmation (IR, NMR), and impurity profiling, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) documenting purity and specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and reacts with water, strong bases, and alcohols. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain purity and reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.