Description

N4-Acetyl-O5'-Trityl-2'Deoxy-Cytidine is a key protected nucleoside derivative, specifically engineered for advanced oligonucleotide synthesis. This compound is critical for researchers and manufacturers requiring high-purity intermediates to ensure the fidelity and yield of complex nucleic acid sequences. It is primarily utilized in the development of antisense oligonucleotides, primers, probes, and other sophisticated bioconjugates within the pharmaceutical and biotechnology sectors.

Application

• Solid-Phase Oligonucleotide Synthesis: Serves as a crucial phosphoramidite building block for the automated synthesis of DNA and RNA strands.
• Antisense Drug Development: Used in the research and production of therapeutic oligonucleotides targeting specific genes.
• Diagnostic Probe Manufacture: Essential for creating labeled probes used in PCR, sequencing, and microarray technologies.
• Academic & Industrial Research: A vital reagent for studying nucleic acid chemistry, modification, and function in R&D laboratories.
• Bioconjugation: Acts as a starting material for creating nucleotide-protein or nucleotide-small molecule conjugates.

Basic Information

Product Name	N4-Acetyl-O5'-Trityl-2'Deoxy-Cytidine
CAS No.	40094-20-0
Molecular Formula	C32H31N3O5
Molecular Weight	537.61 g/mol
Synonyms	1-[(2R,4S,5R)-4-[(Acetyloxy)methyl]-5-[[tris(phenylmethyl)oxy]methyl]oxolan-2-yl]-4-(acetylamino)pyrimidin-2-one; 2'-Deoxy-N4-acetyl-5'-O-tritylcytidine; 5'-O-Trityl-N4-acetyl-2'-deoxycytidine; N4-Acetyl-5'-O-trityl-2'-deoxycytidine; N-Acetyl-5'-O-trityl-2'-deoxycytidine; dC(Ac)Tr; Protected 2'-Deoxycytidine Derivative
EINECS	Contact for details

Quality Control

Our N4-Acetyl-O5'-Trityl-2'Deoxy-Cytidine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.